In Vitro Permeation Testing (IVPT)
As a global leader in complex analytical and bioanalytical testing, we provide solutions and services to the Pharmaceutical, Cannabis, Biopharmaceutical and Nutraceutical industries.
We offer best in class IVPT method development, validation and testing services according to FDA, PSGs, EMA and OECD 428 testing guidelines. Our IVPT testing focuses around the study of skin percutaneous absorption and the cutaneous pharmacokinetics by the determination and evaluation of permeation amount and rate of active compounds. The same testing can also be applied for studying transdermal permeability and metabolic stability of active compounds as well as effects of other composition changes in formulation. Distribution of active compounds in different skin layers can be also investigated.
Our IVPT services support the following studies:
- Formulation Development and Optimization
- Preclinical phase
- Phases I-III studies
- Bioequivalence and Bioavailability
- Irritation assessment (safety evaluation of pharmaceutical or cosmetic)
The in vitro Franz human skin finite dose model has proven to be a valuable tool for the study of percutaneous absorption and the determination of the pharmacokinetics of topically applied drugs. The method has historic precedent for accurately predicting in vivo percutaneous absorption kinetics.
We support the following topically applied dosage forms:
- Pump Sprays
- Topical Aerosols
- Microencapsulation/ Liposomes
- Nail Lacquers
We have extensive experience and expertise in method development and validation of release rate studies for topical formulations, including creams, lotions, ointments, gels, pastes, less viscous solutions and suspensions and transdermal patches for both product development and regulatory purposes.
Download this comprehensive eBook to gain in-depth knowledge of this increasingly popular—but often challenging—testing method for semisolid drugs.