DiTEBA Publishes 11 Page Whitepaper: Predicting Nasal Drug Absorption With In Vitro Release Testing
DiTEBA is pleased to announce the publication of it's latest whitepaper authored by Dr. Theo Kapanadze. This whitepaper investigates the factors influencing nasal membrane permeability and absorption and attempts to demonstrate how in vitro testing methodologies can help you predict nasal drug absorption.
Dr. Kapanadze believes that nasal delivery is a feasible alternative to oral or parenteral administration for some drugs because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The widespread interest in an intranasal route for therapeutic purposes other than the topically nasal drug delivery arises from the particular anatomical, physiological and histological characteristics of the nasal cavity which provides potential for rapid systemic drug absorption and quick onset of action. Therefore, it is crucial to develop in vitro testing methods for predicting nasal drug absorption.
Dr. Kapanadze has posted an article on Diteba's Blog that provides more information on this whitepaper and how you can get the whitepaper.